Abstract
In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.
Highlights
IntroductionMembrane Calcium Pump in Health and Disease. Int
This review focuses on the structure, function and regulation of the plasma membrane calcium pump (PMCA), which is one of a number of membrane Ca2+ -transporting proteins important for maintaining cellular Ca2+ at the low free concentration essential for its signaling function [1]
By using smallangle X-ray scattering (SAXS), we investigated the interaction of calmodulin with peptides of different lengths corresponding to the calmodulin-binding domain of PMCA [70]
Summary
Membrane Calcium Pump in Health and Disease. Int. The extracellular calcium level is adjusted in the millimolar range, basically controlled by seven transmembranes spanning the Ca2+ -sensing receptor, similar to the G-protein-coupled receptor superfamily [4]. This permits Ca2+ to function as a versatile extracellular first messenger. This review focuses on the structure, function and regulation of the plasma membrane calcium pump (PMCA), which is one of a number of membrane Ca2+ -transporting proteins important for maintaining cellular Ca2+ at the low free concentration essential for its signaling function [1]. /CaNa exchanger (NCX) are located in located in themembrane Intracellular organelles such assuch the mitochondrion, the sarco/endoplasmic doplasmic reticulum or the golgi apparatus sequester.
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