Abstract
Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group (p < 0.05). Meanwhile, CP-A significantly increased the activities of SOD and GSH-Px, and decreased the contents of MDA and NO, and the activity of MPO in gastric tissue in a dose-dependent manner (p < 0.05). The present research reported for the first time that inulin-type fructan CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers.
Highlights
Radix Codonopsis is recorded in the Chinese Pharmacopoeia as the dried roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. var. modesta (Nannf.)L
The present study provided insights into the potential of CP-A, an inulin-type fructan isolated from roots of Codonopsis pilosula (Franch.) Nannf., to inhibit ethanol-induced ulcers in rats
The results indicated that the CP-A-treated group (50 mg/kg) showed level 1 gastric damage, which was similar to the positive control group, while the model group exhibited level 3 gastric damage according to the Lacy assay
Summary
Radix Codonopsis is recorded in the Chinese Pharmacopoeia as the dried roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. var. modesta (Nannf.)L. Radix Codonopsis is recorded in the Chinese Pharmacopoeia as the dried roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. Codonopsis tangshen Oliv., and has been used in traditional Chinese medicine for replenishing qi deficiency, strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on [1]. Phytochemical studies indicate that polysaccharides, alkaloids, phenylpropanoids, triterpenes, and polyacetylenes are the main components in Radix Codonopsis [1]. More and more attention has been paid to the study of polysaccharides from Radix Codonopsis. Several such polysaccharides are obtained from Radix
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