Abstract
A severely proton-deficient marine alkaloid (C28H21N7O2) was intractable to structural characterization using only conventional 1D and 2D NMR techniques including HMBC data, which generally provides primarily two- and three-bond correlations. A sensitive, complementary approach to obtain very long-range (≥ 4 J CH) heteronuclear correlations is afforded by the recently reported LR-HSQMBC experiment. An INEPT pulse sequence element inserted after t1 evolution, converts anti-phase long-range heteronuclear coupling information back into in-phase magnetization thereby alleviating cancelation of responses emanating from small (< 2 Hz) scalar couplings. The role of the LR-HSQMBC experiment in the determination of this natural product structure will be illustrated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
