Abstract
The sponge Petrosia sp. yielded five polyacetylenic compounds (1–5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1–5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.
Highlights
IntroductionSince the early days of marine natural products chemistry, sponges (Porifera) have occupied a superior place in the focus of researchers aiming to reveal the therapeutic potentials of these benthic organisms [1]
Since the early days of marine natural products chemistry, sponges (Porifera) have occupied a superior place in the focus of researchers aiming to reveal the therapeutic potentials of these benthic organisms [1].Thousands of secondary metabolites have been identified from these organisms and their contributions to the chemical library continue with fascinating results
Three compounds 3–5 were found to be identical to the known polyacetylenes
Summary
Since the early days of marine natural products chemistry, sponges (Porifera) have occupied a superior place in the focus of researchers aiming to reveal the therapeutic potentials of these benthic organisms [1]. Thousands of secondary metabolites have been identified from these organisms and their contributions to the chemical library continue with fascinating results. Such a sponge-centric theme comes as no surprise, because such organisms have been spotted since antiquity and their unique secondary metabolites suggested a myriad of potential applications [2,3,4]. Among the well-studied Porifera genera is Petrosia sp They have been subjected to intensive scrutiny following the separation of different acyclic polyacetylenes with potent biological activities from sponges belonging to this genus [5,6,7]. Against human T cell lymphoblast-like cell line (CCRF-CEM), human T lymphoblast, acute lymphoblastic leukemia (MOLT-4), human chronic myelogenous leukemia (K-562), human colon adenocarcinoma (DLD-1), human prostate carcinoma (LNCaP) and human hormone-dependent breast cancer (T-47D) cell lines was evaluated
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