Structure Design of Thermosensitive Oligopeptide Hydrogel fro Drug Delivery

Abstract

The first part of this thesis focuses on a slight change in the functional group of the oligopeptide block incorporated into the Poloxamer triblock copolymer that led to drastically different hierarchical assembly behavior and rheological properties in aqueous media for the application as thermo-sensitive hydrogel. Another work presents a new thermosensitive biocompatible oligopeptide-containing hydrogel which is novel for carrying antibody drug - bevacizumab with extended release. The accumulative extended release of bevacizumab in vitro from hydrogel was approximately 90% over a period of one month. Moreover, the in vitro cytotoxicity of oligopeptide-containing Poloxamer copolymer aqueous solution was found to be low on the human retinal pigment epithelial cells. These results not only resolve how the change of the peptide functional group would modify the secondary structure supramolecular assembly behavior and rheological properties of the block copolymer (chapter 3), but also identify a new biocompatible thermo-sensitive hydrogel with low critical gelation concentration (CGC), which may be used in typical diffusion-controlled drug release (chapter 4). In summary, the oligopeptide thermosensitive hydrogel can be used in the field of drug delivery is described in this thesis.