Abstract
Due to the advent of high throughput sequencing techniques and structural genomic projects, the number of gene and protein sequences has been ever increasing. Computational methods to annotate these genes and proteins are even more indispensable. Proteins are important macromolecules and study of the function of proteins is an important problem in structural bioinformatics. This paper discusses a number of methods to predict protein functional site especially focusing on protein ligand binding site prediction. Initially, a short overview is presented on recent advances in methods for selection of homologous sequences. Furthermore, a few recent structural based approaches and sequence-and-structure based approaches for protein functional sites are discussed in details.
Highlights
Proteins bind with other molecules to bolster or inhibit biological functions
This paper discusses a number of methods to predict protein functional site especially focusing on protein ligand binding site prediction
There have been a lot of progress and new types of methodology developed for protein functional site prediction
Summary
Proteins bind with other molecules to bolster or inhibit biological functions. In all these protein and the binding partner (ligand) interaction, usually a few key residues are involved. There have been a lot of progress and new types of methodology developed for protein functional site prediction. In this regard, this paper aims to briefly describe some of the recent developments in the field of protein functional site prediction for structure-based approaches and sequence-and-structure based approaches. A detailed overview on structure-based approaches and sequence-and-structure based approaches for protein functional site prediction is presented
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