Abstract

The permeability of the septate junction of the nephrocytes of Helix pomatia from the basal lamina to lumen has been studied with two electron opaque tracers, horse-radish peroxidase and lanthanum. Ultrathin sections of tissues from animals treated with these materials showed that the septa offer a considerable restraint to the movement of horse-radish peroxidase, but that the lanthanum permeates the septate region of the junction. Tangential sections of lanthanum-infiltrated junctions showed that the septa are corrugated sheets. The infiltration by lanthanum shows that in some areas there are discontinuities in these sheets which may allow the passive movement of solutes from the intercellular space to the kidney lumen.

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