Abstract
Three trends are seen in the organization of ribosomal DNA genes during evolution: 1) gradual separation and separability of the regulation of transcription of 5S and larger subunit rRNAs; 2) retention of a transcription unit containing both large and small rRNAs; and 3) clustering of genes for both 5S and 18S–28S rDNAs, with the possible association of other ‘non-rDNA’ in the clusters of 18S–28S rDNA genes by the time mammals evolve.
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