Abstract
The structures of three new sesqui-neolignans, fargenin ( 1) and fargenones A and B ( 2 and 3), together with two previously known sesqui-neolignans, macranthol ( 4) and isodunnianol ( 5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1– 3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed. Among the isolated sesqui-neolignans, isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 μM in the primary cultured rat cortical neurons.
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