Abstract
The physical principles of a new approach to the investigation of enzymes are discussed, including relaxation versions of the spin label method and also the methods of triplet, Mössbauer, electron-scattering, photochrome and radical pair labels and probes. The combined approach is demonstrated with examples from studies of the structure, dynamics and reaction mechanism of the metallo-enzyme nitrogenase, photosynthetic reaction centers, cytochrome P-450, etc. Some general concepts which emerge in connection with these data (the multielectron mechanism of redox reactions, long-distance electron transfer in proteins, the chemical mechanism of bioenergetic coupling, the cascade mechanism of charge photoseparation, and the crystalline-amorphous dynamical model of proteins) are considered.
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