Abstract
We are still in the early stages of discovery of the full range of biological activity of a newly discovered and most interesting family of human pathogens, the human T-cell leukemia viruses (HTLVs). This chapter is intended as a rough roadmap of the salient features of the viral genome. This overview is based in large measure on the sequence of one strain of HTLV that was obtained from lymphocytes of a patient with adult T-cell leukemia in Japan. Information is also drawn from protein sequence analysis and DNA sequence analysis of several other strains of HTLV isolated from patients with adult T-cell leukemia (ATLL) or acquired immune deficiency syndrome (AIDS) in our own laboratory. Similarities to other retroviruses are noted. The limits of our present knowledge will be outlined.
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