Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States.

Guoying Zhu,Qing Fang,Changqing Yang,Dongping Huang,Fengshang Zhu

doi:10.3389/fgene.2021.693538

Guoying Zhu, Qing Fang + Show 3 more

Open Access

https://doi.org/10.3389/fgene.2021.693538

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Abstract

Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PTL or PNLIP) and its family members, pancreatic lipase-related protein 1 (PNLIPRP1or PLRP1) and pancreatic lipase-related protein 2 (PNLIPRP2 or PLRP2). Unlike the family’s other members, PNLIPRP2 plays an elemental role in lipid digestion, especially for newborns. Therefore, if genetic factors cause gene mutation, or other factors lead to non-expression, it may have an effect on fat digestion and absorption, on the susceptibility to pancreas and intestinal pathogens. In this review, we will summarize what is known about the structure and function of PNLIPRP2 and the levels of PNLIPRP2 and associated various pathological states.

Highlights

Effective digestion and absorption of dietary fats is important, which begins in the stomach by preduodenal lipase with a small amount of dietary triglyceride (Miller and Lowe, 2008)
The purpose of this paper is to review the structure and function of PNLIPRP2 and the relationship between the expression of PNLIPRP2 and various pathological states
The structural parameters are responsible for the substrate specificity among these structural enzymes, and the degree of activity depends on the substrate and PNLIPRP2 species

Summary

Introduction

Effective digestion and absorption of dietary fats is important, which begins in the stomach by preduodenal lipase with a small amount of dietary triglyceride (Miller and Lowe, 2008). The partially digested emulsion particles empty into the duodenum, where it mixes with the pancreatic lipase secreted from the pancreas. Pancreatic lipase is critical for the digestion and absorption of dietary fats. The most abundant lipolytic enzymes secreted by the pancreas are pancreatic triglyceride lipase (PNLIP or PTL) and its family members, pancreatic lipase-related proteins 1 and 2 (PNLIPRP1/PLRP1 and PNLIPRP2/PLRP2). PNLIPRP2 should have some different properties with PNLIP and plays a pivotal role in lipid digestion, especially for PNLIPRP2 and Pathological States newborns. The purpose of this paper is to review the structure and function of PNLIPRP2 and the relationship between the expression of PNLIPRP2 and various pathological states

Objectives

Conclusion