Abstract
The human L23 (mitochondrial)-related protein gene, located 40 kb downstream of the imprintedH19gene, is biallelically expressed. We have cloned and characterized its mouse homolog,L23mrp,which maps to the conserved syntenic region on mouse chromosome 7. The promoter ofL23mrpis a CpG island that is transcribed ubiquitously, but at different levels, in different fetal tissues. Allele-specific expression analysis revealed that both parental alleles are equally active. Since the enhancers located betweenH19andL23mrphad been shown to be involved in the imprinted expression ofIns-2, Igf-2,andH19,we asked whether they also influenceL23mrp.Analysis of mice with a targeted deletion of the enhancers demonstrated that they were not disrupted in the expression ofL23mrp.These findings indicate thatL23mrpis functionally insulated from theIns-2/Igf-2/H19domain in terms of both imprinting and enhancer action.
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