Abstract
In this paper we shall describe some of our recent studies on the structure and catalytic properties of DNA polymerases a and 8 (1) that we have purified from cultured human KB cells and from adult human livers. The principal topics of discussion will be the definition of the polypeptide composition of near homogeneous KB cell DNA polymerase a, the problem of the intracellular localization of polymerase a, and the results of our initial studies on the specific in Vitro replication of human D-loop mitochondrial DNA (mtDNA) by near homogeneous human DNA polymerase
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