Structure and bioactivity of cholestane glycosides from the bulbs of Ornithogalum saundersiae Baker

Abstract

Eight undescribed cholestane glycosides named osaundersioside A-H, along with three previously known compounds named osaundersioside I–K were isolated from Ornithogalum saundersiae Baker bulbs (Asparagaceae). Their structures were elucidated by extensive spectroscopic analysis and chemical methods. All isolates were evaluated for their cytotoxic activity and inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Osaundersioside C was thus determined to exhibit specific cytotoxicity towards MCF-7 cell line with an IC50 value of 0.20 μM, Osaundersioside H exhibited inhibitory effect on NO production in macrophages at the concentration of 10−5 M, with inhibition rate of 56.81%.