Structure activity relationships of selected naphthalene derivatives

Abstract

Twenty-two derivatives of naphthalene were assayed under an acute static regime with biological activity being monitored as population growth of Tetrahymena pyriformis. Activity varied over one log unit. Substituent constant structure-activity analyses revealed the model, log BR = 0.282Ha + 0.352 π + 0.692 F + 0.334 1 X sub v − 0.326 R + 0.027, to be best and to account for 85% of the variation in log BR (BR, biological response; Ha, hydrogen acceptance; π, hydrophobic substituent constant; F, polar electronic substituent constant, 1 X sub v, substituent molar connectivity index; R, resonance electronic substituent constant). The Ha and π parameters are the most important, accounting for 71% of the log BR variability.