Abstract
Most plant-derived phenolic compounds are synthesized as secondary metabolites in plants due to their defense strategies. Previous studies have reported the inhibitory effect of chalchones, one of polyphenols, on nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB)-dependent transcriptional activities in various cancer cells. However, detailed relationship between the structure and biological activity on the inhibition of NF-κB in the microglia is less defined. In this study, twenty-two polyphenols including sixteen hydroxy/methoxy chalcones, four 2H-chromenes, and two N-phenylacetamides were synthesized. Lipopolysaccharide (LPS) is a constituent of the outer membrane of the Gramnegative bacteria, which is widely employed as a proinflammatory stimulus in many experimental settings. The effects of polyphenol compounds synthesized on the inhibition of LPS-induced NF-κB activity in BV2 microglial cells were investigated, and the structural conditions to show better inhibitory effects were evaluated. Western blot analysis was performed on compounds showing good inhibitory effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Korean Society for Applied Biological Chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
