Abstract
AbstractThe effect of aryltin compounds (Ar4Sn and Ar3SnCl) on the growth ofCeratocystis ulmi, the causative agent of Dutch elm disease, was studied in shake culture. In all cases, the triaryltins were more effective than the tetra‐aryltins as inhibitors ofC. ulmi in vitro.Furthermore, substitution on the phenyl ring at themeta‐ andpara‐ positions in the triaryltins did not have a major effect on the biocidal activity for the substituted triaryltins. Quantitative structure–activity relationships (QSARs) gave support to the idea that the species responsible for the inhibition of the fungus is the triaryltin cation. The QSARs further suggest that the interaction of the triaryltin cation with the fungal cell wall ofC. ulmiis by a non‐specific mechanism.
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