Abstract
Dihydrotestosterone glucuronide (DHTG), a series of 5α-bile acids, or allo-bile acids (3α-hydroxy-5α-cholanic acid, 3-keto-5α-cholanic acid and 3β-hydroxy-5α-cholanic acid) and their normal bile acid analogues (3α-hydroxy-5β-cholanic acid or lithocholate, 3-keto-5β-cholanic acid and 3β-hydroxy-5β-cholanic acid) were administered intravenously to female rats in order to determine their effects on bile flow. All agents caused a rapid and profound inhibition of bile flow which was dose-dependent. The logarithm of the dose vs the cholestatic response curve for DHTG, the allo-bile acids and lithocholate were all parallel. DHTG was the most potent congener and was two times more potent than 3-keto-5α-cholanic acid and 5 times more potent than lithocholate. These data indicate that the glucuronic acid moiety and the trans configuration of the A and B rings of the steroid nucleus confer the greatest cholestatic potency.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
