Abstract
Cholesterol ester transfer protein is a plasma glycoprotein synthesized by the liver. Inhibitors of this protein have been researched to treat dyslipidemia. The purpose of this study was to use the computer-aided drug design technique to screen the structures of compounds from the traditional Chinese medicine database and optimize them as new cholesterol-lowering drugs. Molecular docking using 248 chemical compositions of traditional Chinese medicines with cholesterol ester transfer protein was performed. The parent structure “resveratrol” was selected and optimized as the matrix structure. A series of 4-[2-(3,5-dimethoxy-phenyl)-vinyl]-phenylamine analogues were synthesized and characterized by spectroscopic and spectrometric methods.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
