Abstract
Quantitative multiparameter structure-activity studies have been performed on a series of 2-substituted isonicotinic acid hydrazides (Fig. 1). Isonicotinic acid hydrazide (INH) has been one of the most effective drugs in tuberculosis therapy since 1952 when its antibacterial activity against Mycobacterium tuberculosis was discovered [1, 2]. Numerous derivatives have been prepared since then, however, none of them possessed a higher activity than INH itself.
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