Structurally diverse sulphur-containing amides from Glycosmis craibii with their potential antiproliferative activities

Abstract

Fourteen new sulphur-containing amides, glycocramides A-N (1–14), as well as nine known analogues (15–23) were isolated and characterized from Glycosmis craibii Tanaka. The chemical structures of new sulphur-containing amides 1–14 were ambiguously elucidated by extensive spectroscopic methods, while the known compounds 15–23 were identified by the comparison of their experimental spectral data with those described data in the literatures. The antiproliferative effects of all isolated sulphur-containing amides were evaluated in vitro. As a result, part of sulphur-containing amides showed remarkable inhibitory effects against MGC-803 cell line with IC50 values ranging from 13.12 ± 0.10 to 20.03 ± 0.13 μM. These research results suggest that the sulphur-containing amides are potentially to be developed as a new natural anti-tumor drugs.