Abstract
Naringenin is a well-known flavanone with well-established radical scavenging and antioxidant properties. Its biological potency is strongly related to its potential to chelate with biologically active transition metal ions generating novel metal-based drugs with optimized pharmacological properties and biochemical activity. In this work, the thorough physico-chemical characterization and structural determination of two newly synthesized heteroleptic complexes of Cu(II) ion with naringenin and the ancillary aromatic chelators 2,2′-bipyridine and 1,10-phenanthroline is presented. The new complex assemblies were evaluated for their in vitro antioxidant capacity via the 2,2-diphenyl-1‑picrylhydrazyl assay, both displaying significant radical scavenging efficiency and setting the base for further examination of their pharmacological effects.
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