Abstract
We report the crystal structure analysis of the glucocorticoid drug amcinonide from high-resolution X-ray powder diffraction data, with an uncommonly large number of atoms (142, including H) and Z′ = 2; which was carried out through the stepwise location of the rigid and flexible fragments of the asymmetric unit, using the knowledge of steroidal conformations, bond length and angles, and hydrogen bonding packing motifs extracted from the Cambridge Structural Database. The database search also provided an experimental framework used to compare the main attractive intermolecular interactions found in amcinonide with those of related steroids, in order to contribute to the systematization of likely factors often leading to Z′ > 1 structures in this type of compound. These were found to be the presence of the functional groups –COOH and multiple –OH, as well as hydrated structures, wherein varied H-bonding patterns are formed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
