Abstract
Mitochondrial fission protein 1 (Fis1) and dynamin-related protein 1 (Drp1) were initially described as being evolutionarily conserved for mitochondrial fission. However, the role of human Fis1 in this process remains unclear. In budding yeast, where Fis1 helps to recruit Drp1 from the cytoplasm to mitochondria for fission, the N-terminal “arm” of Fis1 is required for function. The yeast Fis1 arm interacts intramolecularly with a conserved concave surface that governs in vitro interactions with yeast Drp1.
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