Structural rearrangement and degradation mechanisms of amyloids in extreme temperatures and solvents

Abstract

Amyloids and protein aggregates formed from commonplace whey or plant proteins have found increasingly diverse applications as coatings, food packaging, and carriers in drug delivery. Whey- and plant-derived amyloid materials are attractive biomaterials due to their low cost, thermal and environmental phase transition properties, and ability to survive high temperatures and in non-aqueous solvents. Despite their use as structural materials in synthetic environments, little is known about the limits of amyloid stability at such extreme conditions.