Abstract
A refined topographical model of adenovirus type 2 was constructed based on results with enzymatic iodination of intact and disrupted virions and immunoprecipitation of intact virions with specific antisera. Results with reversible chemical cross-linkage of the structural proteins support this model, which suggests that proteins VI, VII and VIII are located within the virion. The core protein V is also an internal protein probably located at the vertices in close connection with the penton bases, hexons and protein IIIa molecules. Proteins IIIa and IX apparently lack tyrosine residues exposed on the outside of the virion but have external antigenic determinants.
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