Abstract
BackgroundThis study examines the effects of adding gelatin to a starch-chitosan composite foam, focusing on the altered structural and biological properties. The compressive modulus of foams containing different gelatin concentrations was tested in dry, wet, and lyophilized states. MC3T3 mouse osteoblast cells were used to test the composite’s ability to support cell growth. The stability of the foams in α-MEM culture media with and without cells was also examined.ResultsIt was found that for dry foams, the compressive modulus increased with increasing gelatin content. For foams tested in wet and lyophilized states, the compressive modulus peaked at a gelatin concentration of 2.5% and 5%, respectively. The growth of MC3T3 mouse osteoblast cells was tested on the foams with different gelatin concentrations. The addition of gelatin had a positive effect on the cell growth and proliferation.ConclusionThe composite foam containing gelatin improved cell growth and is only dissolved by the growing cells at a rate influenced by the initial concentration of gelatin added to the foam.
Highlights
This study examines the effects of adding gelatin to a starch-chitosan composite foam, focusing on the altered structural and biological properties
These positive charges will cause gelatin to interact with the starch, precluding some amount of interaction with the chitosan reducing the overall degree of electrostatic complexation
Adding gelatin to the mixture resulted in an increase in compressive modulus in the dry foam
Summary
This study examines the effects of adding gelatin to a starch-chitosan composite foam, focusing on the altered structural and biological properties. The compressive modulus of foams containing different gelatin concentrations was tested in dry, wet, and lyophilized states. Chitosan is an example of such a biomaterial. This is in large part due to its ability to form polyelectrolyte complexes with negative polyanions in solution at a low pH [3]. Chitosan-based scaffolding has been studied with many other types of polymers. Some examples of these include silk fibroin, collagen, alginate, and gelatin [5,6,7,8]
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