Abstract

The synthesis and characterization of the silver(I) chloride complex of formula {[AgCI(CMBZT)(TPTP)2] · (MeOH)} (1) (CMBZT = 5-chloro-2-mercaptobenzothiazole, TPTP = tris(p-tolyl)phosphine) is described. Also the structure of the hydrate derivative {[AgCI(TPTP)3] · (0.5 · H2O)} (2) of the corresponding known anhydrous silver complex (Zartilas et al., 2009), and the polymorph 3 of the known [AgI(TPTP)3] complex (Zartilas et al., 2009) were determined and compared with the known ones. In addition, the structure of the known one silver(I) cluster {[AgI(TPTP)]4} (4) (Meijboom et al., 2009) was re-determined at 120(2) K and possible Ag-Ag interactions were analyzed. The compounds 1–4 were characterized by X-ray crystallography at r.t (1) and 120 K (2–4). All these complexes and {[(Et3NH)+]2 · [Ag6(μ 3-Hmna)4(μ 3-mna)2]2− · (DMSO)2 · (H2O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity. The in vitro testing of cytotoxic activity of 1–5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays. The flow cytometry assay for complex 1 and showed that at 15 μM of 1, 62.38% of LMS cells undergo apoptosis, while 7% of LMS cells undergo cell necrosis. The antitumor activity of 3 is comparable with that of its reported polymorph (Zartilas et al., 2009). The anti-inflammatory, activity of complexes 1–3 and 5 was also studied. The activity towards cell viability was 2 > 3 > 5 > 1 > 4, while the order of the inhibitory activity in cell growth proliferation follows the order, 2 > 3 > 1 > 4 > 5. The anti-inflammatory activity on the other hand is 1 > 2 > 5 > ⋯ >3.

Highlights

  • Silver(I) complexes with sulfur containing ligands exhibit a wide range of applications in medicine, in analytical chemistry and in the polymer industry [1,2,3,4,5]

  • The results showed that [AgBr(TPTP)3] complex possessed the strongest activity against leukemia (L1210), human T-lymphocyte (Molt4/C8 and CEM) and leiomyosarcoma cancer cells (LMS) cells [12]

  • The crystal structure of 4 {[AgI(TPTP)]4} has been previously reported at 100(2) K [31] but we have extended our studies here in the determination of its quasiaromaticity, which results in strong Ag–Ag interactions and greater stability, using data collected at 120 K

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Summary

Introduction

Silver(I) complexes with sulfur containing ligands exhibit a wide range of applications in medicine, in analytical chemistry and in the polymer industry [1,2,3,4,5]. The ability of silver(I) complexes to adopt geometries with variable nuclearities and structural diversity makes the study of silver(I) chemistry very attractive [3,4,5, 17]. This self-assembly process between metal ions and ligands is known to depend on steric and interactive information stored in the ligand and is governed by the metal ions through the demands of their coordination geometry [18, 19]. The anti-inflammatory activity of complexes 1–3 and 5 were evaluated and the results correlated with those of their anti-tumor activity

Results and Discussion
Biological Tests
Conclusions
Experimental
Anti-Inflammatory Activity
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