Abstract
The location of the peaks of the circumpapillary retinal nerve fiber layer (cpRNFL) thickness is affected by several ocular parameters. In this study, we have generated equations that can determine the peaks of the cpRNFL. This study was a prospective, observational, cross sectional study of 118 healthy right eyes. The axial length, optic disc tilt, superiortemporal (ST)- and inferiortemporal (IT)-peaks of the cpRNFL thickness, and angles of the ST and IT retinal arteries (RA) and veins (RV) were determined. The correlations between the location of the ST- and IT-peaks and ocular structural parameters and the sex, body height and weight were calculated. The best fit equations to generate the location of the ST/IT-peaks were determined using corrected-Akaike Information Criteria. The location of the ST-peak was 0.72+(0.40 x ST-RA)+(0.27 x ST-RV)+(0.14 x height)–(0.47 x papillo-macular-position)–(0.11 x disc tilt) with a coefficient of correlation of 0.61 (P<0.0001). The location of the IT-peak was 21.88+(0.53 x IT-RA)+(0.15 x IT-RV)+(0.041 x corneal thickness)-(1.00 x axial length) with a coefficient of correlation of 0.59 (P<0.0001). The location of ST/IT peaks is determined by different parameters of the ocular structure. These equations allow clinicians to obtain an accurate location of the peaks for a more accurate diagnosis of glaucoma.
Highlights
The axons of the retinal ganglion cells (RGCs) can be damaged in eyes with increased intraocular pressure, i.e., glaucomatous eyes, and the damage is irreversible
The results of earlier studies suggested that the structural changes around the optic nerve head (ONH) [1]. and the thickness of the retinal nerve fiber layer (RNFL) around the optic disc [2] preceded the visual field (VF) defects
The study was approved by the Ethics Committee of Kagoshima University Hospital, and it was registered with the University Hospital Medical Network (UMIN)-clinical trials registry: “Morphological analysis of the optic disc and the retinal nerve fiber in myopic eyes”
Summary
The axons of the retinal ganglion cells (RGCs) can be damaged in eyes with increased intraocular pressure, i.e., glaucomatous eyes, and the damage is irreversible. An early diagnosis of glaucoma is essential in preventing this damage. The thickness of the retinal nerve fiber layer (RNFL) around the optic disc [2] preceded the visual field (VF) defects. The results of earlier studies suggested that the structural changes around the optic nerve head (ONH) [1]. Assessment of these parameters in eyes suspected of having glaucoma is important for an early diagnosis of glaucoma.
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