Structural, Optical and Antimicrobial Activity of Cu Doped HAp: Synthesized by Solgel Method for Biomedical Applications

Abstract

Hydroxyapatite is the thermodynamically most stable crystalline phase of calcium phosphate in body fluid. Undoped hydroxyapatite (HAp) and two Cu substituted HAp samples with variable amounts (0.04 and 0.06)% of Cu were synthesized by sol–gel method. The samples were studied by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray (EDX) spectroscopy to determine the crystallite size, functional groups and elemental composition respectively. The calculated dimensions of crystallites appeared to be within 25-59 nm. The average crystallite size derived from XRD data was observed to be reduced from undoped HAp to substituted HAp samples. The intensity of XRD peaks decrease from undoped HAp to Cu doped HAp. The bands at different modes are observed by FTIR spectrum. The band at 3641 cm−1 was also associated with the O-H stretching mode of the surface P-OH groups. The EDX results confirmed the composition of the doped and undoped HAp. The antimicrobial effects of doped hydroxyapatite powders against clinical pathogen Shigella flexneri.