Abstract
The purpose of our study was to estimate the ability of structural MRI-based texture analysis (TA) to quantify the textural changes in corpus callosum (CC) caused by Progressive Supranuclear Palsy (PSP). Three distinct TA approaches: gray level co-occurrence matrix (GLCM), local binary pattern (LBP), oriented Gaussian derivative filter-bank (O-GDFB) were exploited and compared to present a novel study that can classify PSP ( $\mathbf{n}=16$ ) by quantifying the textural changes in CC versus that in healthy controls $(\mathbf{HC}, \mathbf{n}=16$ using T1-W MRI. Different statistical texture features were extracted using GLCM and LBP, from the five distinct CC sub-regions: CC1 (genu), CC2 (anterior-mid), CC3 (mid-body), CC4 (posterior-mid) and CC5 (splenium). Unlike statistical based TA, a modified GDFB based TA was also performed to explore the differences in filter responses in the same CC sub-regions for different orientations and scales. Finally, texture features that showed statistically highest discrimibility were input to the SVM classifier in classifying PSP and HC. With leave-one-out cross validation, SVM classification results maximum accuracy of 88%, 94% and 84% at CC3 using GLCM, LBP and O-GDFB based TA respectively. The diagnostic potential of CC TA using structural MRI can be applied on routine radiology scan without needing any additional acquisition for quantitative analysis. Significant texture alteration found at CC3 may be of great importance in the diagnosis and understanding of this pathology.
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