Abstract
Using baicalin,the main active component of a traditional Chinese herb Scutellaria baicalensis, and one of its derivative,6,7-diacetoxylbaicalein,as precursors,a series of C8-substituted and di or tri-O-methylated baicalein derivatives was synthesized in good yields by iodination,nitration,reductive amination and selective methoxylation or hydrolysis of 6,7-diacetoxylbaicalein.The structures of these producrs were characterized.They featured with a broad spectrum of biological activities,notably anti-oxidant.
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