Abstract
Introduction. 7-33 % of women and 4-5 % of men have low blood pressure. Hypoperfusion of human s organs reduces the quality of life leading to myocardial malnutrition, and is associated with increased blood viscosity. The maintenance of a comprehensive study of the mechanisms of keeping blood pressure in the early stages of arterial hypotension effects on the body is of big interest. The aim of the research is to study the structural - functional characteristics of the myocardium and blood rheology of young women with low blood pressure. Material and methods. The object of the study were young women (age 19-23 years). Test group: 31 people with systolic blood pressure of 98 mm Hg and lower; Control group: 25 people with systolic blood pressure 120-129 mmHg. Study Type - single-step. Methods used: echocardiography, blood viscometry, quantitative analysis of hemogram and morphology of red blood cells. The test and control groups were similar in age, height, heart rate, blood volume circulating. Results and discussion. Women test group had a lower weight, a smaller thickness of the rear wall of the left ventricle to systole and septum to systole and diastole (p = 0.00-0.03). There were no difference between groups in the parameters of cardiac hemodynamics, minute volume of blood, quantitative indicators hemogram, blood viscosity, aggregation and deformability of red blood cells. In the test group, percentage poikilocytosis (23 %) is 4.5 times higher compared with the control group (5 %), p = 0.00. In the test group PWTs is correlated with blood viscosity at a shear rate of 20 s-1 (r = -0.38), the number of leukocytes (r = -0.36), red blood cells (r = -0.37), hemoglobin (r = - 0.44), hematocrit (r = -0.45), in the control group is correlated with erythrocyte aggregation index (r = -0.43), p <0.05. Conclusions. Reduction of the left ventricular wall thickness of young women with idiopathic arterial hypotension does not reduce minute volume of blood, but negatively correlates with blood viscosity and hematocrit. Young women with idiopathic arterial hypotension lack compensatory increase in blood viscosity. Being present increasing poikilocytes in the test group is a predictor of increasing the viscosity of the blood, which in course of time can lead to aggravation of perfusion abnormalities.
Highlights
Hypoperfusion of humans organs reduces the quality of life leading to myocardial malnutrition, and is associated with increased blood viscosity
There were no difference between groups in the parameters оригинальные статьи of cardiac hemodynamics, minute volume of blood, quantitative indicators hemogram, blood viscosity, aggregation and deformability of red blood cells
Percentage poikilocytosis (23 %) is 4,5 times higher compared with the control group (5 %), p = 0,00
Summary
Зависимость между двумя переменными внутри групп изучали с помощью коэффициента ранговой корреляции Спирмена [6]. Результаты исследования и их обсуждение Женщины с ИАГ имели меньшую толщину стенок миокарда левого желудочка, преимущественно межжелудочковой перегородки. При этом размеры полости левого желудочка в тестовой и контрольной группах были одинаковы Не обнаружено также различий между группами в показателях ИММЛЖ, МО, максимальных скоростях трансмитрального кровотока, а также в соотношении Ve/Va. Показатели реологии крови и гемограммы представлены в таблицах 3 и 4. Нами не выявлена разница в вязкости крови на разных скоростях сдвига, свойствах эритроцитах, количественных показателях гемограммы между группами. В тестовой группе имели место корреляции ТЗСЛЖс с вязкостью крови при скорости сдвига 20 с–1 (r=–0,38), количеством лейкоцитов (r=–0,36), эритроцитов (r=–0,37), гемоглобина (r=– 0,44), гематокритом (r=–0,45), р
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