Structural-functional changes in the muscle of the men which have been transferred by epididymoorchitis

Abstract

The study of structural and functional changes in the testis under conditions of epididymorrhitis is important for urology and andrology, because changes in blood vessels, testicular parenchyma, and ejaculate adversely affect reproductive function. leading to the development of infertility. Most clinicians view epididymoorchitis not as an individual disease, but as part of the infectious-inflammatory process of the entire reproductive system. Most cases of epididymorrhitis in men 36-45 years are caused by a sexually transmitted infection, in particular Neisseria gonorrhoeae and Chlamydia trachomatis, via the familial duct. Nonspecific epididymoorchitis in men aged 36-60 years is most often (80 %) caused by enterobacteria and especially Escherichia coli. Methods of angiography, microscopy of testicular biopsy specimens, laboratory diagnosis of ejaculate, electron microscopy and statistics revealed that in men who underwent epididymorchitis, testicular atrophy develops with a decrease of 25 %, 23 % of the diameter of the truncate of the bowel, 32 % of them are cells of spermatogenic epithelium are not identified, in 45 % of tubules there are severe disorders of spermatogenesis. The total number of spermatogonia is reduced by 45 %, spermatocytes and spermatids – by 64 %. In the interstitium lymphocytic infiltration, growth of connective tissue elements is expressed. Interstitial endocrinocyte nucleus volume decreases by 31 %. In myoid cells, supporting epitheliocytes, interstitial endocrinocytes, endocrinocytes of hemocapillaries – homogenization of mitochondrial crystals, deformation of structures of the Golgi complex and endoplasmic reticulum are deformed. The concentration of sperm in the ejaculate is reduced by 80 %, the number of pathological forms of sperm increases in 3 times, their mobility decreases