Structural features of vestibule of the vaginas’ small glands in newborn girls with anomalies of internal genital organs

Abstract

The purpose of the study was to identify the structural features of the small glands of the vestibule vagina with some anomalies in the development of internal genital organs. Material and methods. Glands of the vaginal vestibule of 18 newborn girls with internal genital anomalies were examined histologically using light microscopy. The comparison group consisted of 10 cases of newborn girls without pathological changes in the urogenital apparatus. After separation of the vestibule from the surrounding structures from the organ wall, longitudinal fragments were cut out, which were fixed in formalin and, after posting on alcohols, an increasing concentration was poured into paraffin. Sections 5-7 microns thick were stained with hematoxylin-eosin and by Van Gieson. Craigberg reaction was also conducted. The digital data obtained during the study were subjected to statistical processing. Results. The analysis showed that, in norm, the small glands of the vestibule of the child's vagina at the time of birth are capable of active secretion. In newborn girls with anomalies of the uro-genital system, the thickness and area of the initial section, the number of initial parts, the area of the initial part on the cut, the number of glandulocytes in the initial part of the glands decrease. There is an increase in the lumen of the common gland duct. Conclusions. Normally, small glands of the vestibule in the newborn are fully formed. With anomalies of the internal genital organs, significant destructive changes in the glandular apparatus of the vestibule are revealed. In contrast to the norm, the initial parts of the glands on the longitudinal sections are deformed. The thickness and area of the initial section decreases, the number of initial parts, the area of the initial part on the cut, the number of glandulocytes in the initial part of the glands.