Abstract
The aim of the work is to investigation of the structural features of mineral carriers of medicinal substances. Tasks: conduct electron microscopy and study the structural features of mineral sorbents; develop a classification of sorption interaction. The materials are Smectite Dioctahedral (registration certificate N 015155/01, France), Kaolin (state standard 19608-84, Russia), Montmorillonite Clay (technical specifications 9296-001-62646221-2012, Russia). The methods are scanning electron microscopy on a FEI Quanta 600 microscope with a low vacuum mode and an LFD detector. Results. Electron microscopy of objects was performed using segmentation of elements as subsystems, inside which the morphological description does not penetrate. The morphology of objects is studied. It is established that the studied substances are microstructural objects. Porosity was determined in samples of Smectite, Kaolin and Montmorillonite Clay. The classification of sorption interaction is developed. According to the presented classification, the materials under study are divided into two groups according to their porous characteristics: Group 1-sorption interaction in pores and by ion exchange (Smectite, Montmorillonite Clay); Group 2-sorption in secondary pores and by means of Oxygen and Hydroxyl centers (Kaolin).
Highlights
Mineral clays are widely used in medicine and pharmacy
The sorbent acts as a carrier of the drug molecule with its subsequent delivery to the destination by desorption [1]
One of the ways to study the sorption-desorption processes in drug transport systems is to study the morphological structure of the sorption substance
Summary
Mineral clays can be used to create drug transport systems in which the sorption mechanism is used to bind, transport, and isolate the drug molecule. In this case, the sorbent acts as a carrier of the drug molecule with its subsequent delivery to the destination by desorption [1]. One of the ways to study the sorption-desorption processes in drug transport systems is to study the morphological structure of the sorption substance. Morphological structure refers to the aggregate characteristics of elements, including their size, shape, and spatial organization. Knowing the physical and chemical properties of the substance, in particular the surface morphology, it is possible to predict the sorption characteristics [2]
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