Structural features influencing the activity of bis-biguanide ligands in the Suzuki–Miyaura cross-coupling reaction in neat water

Abstract

Catalytic reactions play an integral role in the development of green chemistry. Herein, we report new bis-biguanide compounds containing alkyl and aryl spacers as ligands for the Suzuki–Miyaura cross-coupling reaction in water. These ligands show similar catalytic activity to metformin independently of the nature of the spacer between the two biguanide units.