Abstract
Rabbit aortas were examined by light, scanning and transmission electron microscopy to observe the morphological steps in focal endothelial cell desquamation. The aortas were not subjected to any instrumentation prior to fixation by either immersion or perfusion. In areas where boundary layer separation of flow with eddy formation is known to occur, many elongated protruding injured cells were observed, some obviously partly loosened. Some of the latter cells appeared to be suspended in two ends and were twisted longitudinally. Single cells, or even sheets of cells, were completely detached; the breaks seemed to have taken place close to, and parallel with the intercellular junctions, but not within these structures. Platelets had reacted both with injured cells and the denuded intimai surface. Thus, the sequence appears to be protrusion of cell body, partly loosening of cells through breaks near the periphery, twisting of cells, and complete detachment.
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