Abstract
Quantitative structure activity relationship analysis was performed on a series of thirty-three quinoline derivatives to establish the structural features required for angiotensin II receptor activity. QSAR models were derived by stepwise multiple regression analysis employing the method of least squares, using quantum chemical, thermodynamic, electronic and steric descriptors. Model showed best predictability of activity with cross validated value (q2 ) =0.7485, coeffi cient of determination (r2 ) =0.8734 and standard error of estimate (s) = 0.2690. These guidelines may be used to develop new antihypertensive agents based on the quinoline analogues scaffold.
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