Abstract
The structural determinants identified as associated with carcinogenicity in rodents were compared to the structural determinants associated with mutagenicity in Salmonella and toxicity to cultured cells. The analysis revealed that the determinants of carcinogenicity could be separated into two almost mutually exclusive groups: Those associated with mutagenicity (and electrophilicity) and those associated with cell toxicity. These findings provide evidence for two mechanisms of cancer induction: A genotoxic one and a non-genotoxic one associated with cell toxicity.
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