Abstract
Two new ursane-type triterpenoids with a rare caffeoyl group at C-27, 3β-acetoxy-27-trans-caffeoyloxyurs-12-en-28-oic acid-methyl ester (1) and 3β-acetoxy-27-cis-caffeoyloxyurs-12-en-28-oic acid-methyl ester (2), together with three known triterpenoids (3–5), were isolated from the leaves and twigs of Syzygium handelii. Their structures were elucidated by detailed NMR, MS spectroscopic data interpretation, calculated NMR, and DP4+ methods. Anti-microbial and cytotoxic activities of new compounds were evaluated. Compounds 1 and 2 showed weak cytotoxicity against HepG2 cells with IC50 value of 81.3 and 72.1 μM, respectively. The optimal molecule docking results showed that compounds 1 and 2 could bind stably to COX-2 protein.
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