Abstract
Eight pharmaceutically important 5,5′-disubstituted barbituric acid derivatives were studied by differential pulse polarography (DPP). Borate buffer (0.05 M at pH 9.30) was selected as the best supporting electrolyte for the determination of the substances by DPP. The effects of parameters such as pH, temperature, mercury column height and concentration on peak potential and peak height were also studied to elucidate the electrode processes and to examine the structural relationship between the derivatives. From the effects of the above-mentioned parameters and from the αn values it was concluded that the reaction mechanisms were the same for all the derivatives and the linear free energy relationship (LFER) could be applied. The relationship between polarographic behavior and pharmacological activity was also investigated.
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