Abstract
The purpose of this investigation was to examine the effect of Cobalt-Manganese-Zinc Ferrite nanoparticles (Co0.3Mn0.2Zn0.5Fe2O4 NPs) on DNA structure along with its inhibitory role in the growth of T47D cells. This investigation performed with ultraviolet and fluorescence spectroscopy, zeta potential investigation, circular dichroism (CD) spectroscopy, as well as MTT assay, DAPI staining, and flow cytometry analyses. The ultraviolet and fluorescence results indicated that Co0.3Mn0.2Zn0.5Fe2O4 NPs could form a complex via non-intercalative mechanism. The thermodynamics parameters exhibited that Co0.3Mn0.2Zn0.5Fe2O4 NPs the hydrophobic force plays a role in this interaction. The CD data confirmed that Co0.3Mn0.2Zn0.5Fe2O4 NPs induced the transition of DNA conformation to a compact molecular form so-called Ψ-form, furthermore, DNA was relatively thermally stable in the presence of Co0.3Mn0.2Zn0.5Fe2O4 NPs. The anticancer property of Co0.3Mn0.2Zn0.5Fe2O4 NPs via MTT assay, DAPI staining and flow cytometry analyses verified that this nanoparticle can reduce T47D cells proliferation. Based on this investigation Co0.3Mn0.2Zn0.5Fe2O4 NPs could change the structure of DNA and can affect the cell viability. This study can offer an innovative strategy for designing a new anti-tumor agent.
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