Abstract
What role does intra-domain protein dynamics play in multi-domain protein communication? We answer this from investigations of allosteric communication in a peptide-bond catalyzing domain of a nonribosomal peptide synthetase (NRPS). NRPSs are large, modular, multidomain enzymatic systems that synthesize complex natural products from simple substrates, many with invaluable pharmacological applications. Despite the fascinating diversity of products, NRPSs operate in a conserved assembly-line-like manner.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
