Structural Diversity and Biological Activities of Diterpenoids Derived from Euphorbia fischeriana Steud.

Baiyu Jian,Hao Zhang,Jicheng Liu

doi:10.3390/molecules23040935

Abstract

Diterpenoids are the focus of natural product drug discovery because of their great structural diversity and pronounced biological activities. Euphorbia fischeriana Steud is a Chinese traditional medicinal herb for curing edema, ascites, and cancer. This plant contains rich diterpenoids. Based on the carbon skeleton and substituents, it can be classified into thirteen subtypes: ent-abietane, daphnane, tigliane, ingenane, ent-atisane, ent-rosane, ent-kaurene, ent-kaurane, secotigliane, lathyrane, ent-pimarene, isopimarene and dimeric. In this paper, we reviewed the chemical structures and biological activities of 90 diterpenoids isolated from this medicinal herb. We hope that this work can serve as a reference for further research of these diterpenoids and lay the foundation for drug discovery.

Highlights

Euphorbia fischeriana Steud is a perennial herbaceous plant belonging to the family Euphorbiaceae, which is primarily distributed in northeastern mainland China [1]
We focus on the structures and biological activities of 90 diterpenoids with different structures derived from E. fischeriana
Diterpenoids are a constant focus of drug discovery because of their great structural diversity, resulting in various bioactivities

Summary

Introduction

Euphorbia fischeriana Steud is a perennial herbaceous plant belonging to the family Euphorbiaceae, which is primarily distributed in northeastern mainland China [1]. In the last few years, a tigliane-type diterpenoid prostratin extracted from the roots of E. fischeriana has attracted great interest because of its unique ability to activate latent viral reservoirs and protect healthy cells from infection [5,6]. It is a protein kinase C activator that can reactivate HIV-1 latency and help to avoid the new infection of. Molecules 2018, 23, 935 diterpenoids include ent-abietane, daphnane, tigliane, ingenane, ent-atisane, ent-rosane, ent-kaurene, ent-kaurane, secotigliane lathyrane, ent-pimarene, isopimarene and dimeric 3α,17-dihydroxy-ent-pimara-8(14),15-diene isopimara-9(11),15-diene-3,19-diol ent-8(14)-pimarene-12β,15S,16-triol jolkinol A langduin C langduin D ent-rosane ent-rosane ent-rosane ent-rosane ent-rosane ent-rosane ent-rosane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ent-atisane ingenane ingenane ingenane ingenane ingenane ingenane ent-kaurane ent-kaurene ent-kaurane ent-kaurane ent-pimarene isopimarene ent-pimarene lathyrane dimeric dimeric [14]

Antitumor Activity

Anti-Inflammatory

Anti-HIV-1

Feeding Deterrent

Other Activities

Conclusions