Abstract
MAMMALIAN cells transformed by oncogenic viruses or chemical carcinogens undergo characteristic changes in their surface properties such as lectin-induced cell agglutination1,2. Normal cells show similar changes at their mitotic phase3 or after mild protease digestion of their surface membrane4,5. This suggests that cells change their surface properties under various conditions and during the cell cycle. With this concept in mind, we studied the changes on the membrane surface during the maturation of rabbit erythrocytes. We describe here the changes in cell agglutinability and in the binding sites of concanavalin A (con A) on the cell surface during erythrocyte maturation.
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