Structural connectivity profile of scans without evidence of dopaminergic deficit (SWEDD) patients compared to normal controls and Parkinson's disease patients.

Mansu Kim,Hyunjin Park

doi:10.1186/s40064-016-3110-8

Abstract

BackgroundIn this study, we investigated the structural connectivity profile of patients with scans without evidence of dopaminergic deficit (SWEDD) compared with normal controls (NC) and patients with Parkinson’s disease (PD). An accurate understanding of SWEDD is important so that appropriate therapeutic options can be presented to patients.MethodsDiffusion magnetic resonance imaging of NC (n = 40), SWEDD (n = 40) and PD patients (n = 40) was obtained from a research database. Tractography, the process of obtaining fiber information was performed. Connectivity analysis was performed on 16 connections in the cortico-basal ganglia-thalamo-cortical circuit. Group-wise differences among NC, PD and SWEDD patients were quantified in terms of structural connectivity based on fiber density. Then, we investigated correlations with the clinical score using the Movement Disorder Society-Sponsored Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). A support vector machine classifier and leave-one-out cross-validation were applied to separate the NC, SWEDD and PD groups.ResultsPallidum–putamen and sensorimotor cortex–putamen connections showed significant group-wise differences among NC, PD and SWEDD patients and correlated with the MDS-UPDRS score.ConclusionsPallidum–putamen and sensorimotor cortex–putamen connections might form a structural connectivity profile unique to SWEDD and could be a potential imaging biomarker for future movement disorder research.

Highlights

In this study, we investigated the structural connectivity profile of patients with scans without evidence of dopaminergic deficit (SWEDD) compared with normal controls (NC) and patients with Parkinson’s disease (PD)
Seven connections were smaller in PD compared with NC and two connections were smaller in NC compared with PD (p < 0.05, corrected)
PD patients showed significant connection differences compared with NC in associative cortex–caudate, associative cortex–thalamus, limbic cortex–caudate, limbic cortex–putamen, limbic cortex-thalamus, sensorimotor cortex–caudate, sensorimotor cortex–putamen, pallidum–putamen and pallidum–thalamus connections

Summary

Introduction

We investigated the structural connectivity profile of patients with scans without evidence of dopaminergic deficit (SWEDD) compared with normal controls (NC) and patients with Parkinson’s disease (PD). An accurate understanding of SWEDD is important so that appropriate therapeutic options can be presented to patients. Kim and Park SpringerPlus (2016)5:1421 causes inhibition of basal ganglia output and dysfunction within cortico-basal gangliathalamo-cortical circuits (CBGT) (Obeso et al 2008; Sharman et al 2013). Functional neuroimaging techniques such as 18F dopa positron emission tomography or dopamine transporter single-photon emission computed tomography (DaT-SPECT) are adopted to assess dopaminergic dysfunction in PD patients. Understanding SWEDD is important so that appropriate therapeutic options can be presented to patients

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Discussion

Conclusion