Structural connectivity predicts functional activation during lexical and sublexical reading

Abstract

A critical question in neuroscience is the extent to which structural connectivity of the brain predicts localization of brain function. Recent research has suggested that anatomical connectivity can predict functional magnetic resonance imaging (fMRI) responses in several cognitive domains, including face, object, scene, and body processing, and development of word recognition skills (Osher et al., 2016; Saygin et al., 2016). However, this technique has not yet been extended to skilled word reading. Thus, we developed a computational model that relates anatomical connectivity (measured using probabilistic tractography) of individual cortical voxels to fMRI responses of the same voxels during lexical and sublexical reading tasks. Our results showed that the model built from structural connectivity was able to accurately predict functional responses of individual subjects based on their structural connectivity alone. This finding was apparent across the cortex, as well as to specific regions of interest associated with reading, language, and spatial attention. Further, we identified the structural connectivity networks associated with different aspects of skilled reading using connectivity analyses, and showed that interconnectivity between left hemisphere language and right hemisphere attentional areas underlies both lexical and sublexical reading. This work has important implications for understanding how structural connectivity contributes to reading and suggests that there is a relationship between skilled reading and neuroanatomical brain connectivity that future research should continue to explore.