Structural connectivity of left cortical speech regions defined by direct cortical stimulation during awake language mapping

Abstract

Event Abstract Back to Event Structural connectivity of left cortical speech regions defined by direct cortical stimulation during awake language mapping Christian Kell1*, Pavel Hok2, Silke Fuhrmann1, Ines Kropff3, Marie-Therese Forster3, Christian Senft3 and Volker Seifert3 1 Goethe University, Department of Neurology, Germany 2 Palacky University, Department of Neurology, Czechia 3 Goethe University, Department of Neurosurgery, Germany The location of eloquent cortex is highly variable. Left hemispheric surgery thus requires functional language mapping via intraoperative direct cortical electric stimulation during neuropsychological testing, which provides a detailed functional map of regions that are critically involved in the tested task. Although the patient's brains are abnormal due to mass lesions, these results provide nevertheless insights into general Neurophysiological principles. We previously could not find a clear relationship between individual regions involved in articulation, speech planning and picture naming and individual gyrification. To test whether the lack of clear attributable functional roles of individual gyri was related to different structural connectivity, we obtained pre-operative T1 and DWI datasets (3T, 60 dir) in so far 4 patients and performed probabilistic fiber tracking (FDT in FSL) using 5mm spheres around the functionally positive sites as seeds, yielding posterior probability distribution maps thresholded at the 90th percentile of all non-zero values. Independent of individual function, the triangular inferior frontal gyrus (IFG) projected to more rostral parts of the mesial prefrontal cortex (mPFC) compared to the opercular IFG that projected to the more caudal pre-SMA and lateral articulatory motor cortex (M1). Yet, independently from individual location on a given gyrus, anomia sites projected to the mPFC and locally to the opercular IFG. Speech arrest sites had local projections to frontal operculum, M1 and postcentral gyrus but also long-range connections to the dorsal premotor cortex, pre-SMA and via the arcuate fascicle to the posterior middle temporal gyrus. Even adjacent sites on the same gyrus that differed in function showed dissociable structural connectivity. Our results suggest that structure-function relationships are more evident between function and structural connectivity than between function and gyrification. This implies a developmental dissociation between gyrification and functional specialization. Keywords: direct cortical stimulation, structural connectivity, Language mapping, awake brain tumor surgery, probabilistic fiber tracking Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Language Citation: Kell C, Hok P, Fuhrmann S, Kropff I, Forster M, Senft C and Seifert V (2015). Structural connectivity of left cortical speech regions defined by direct cortical stimulation during awake language mapping. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00213 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Dr. Christian Kell, Goethe University, Department of Neurology, Frankfurt, Germany, c.kell@em.uni-frankfurt.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Christian Kell Pavel Hok Silke Fuhrmann Ines Kropff Marie-Therese Forster Christian Senft Volker Seifert Google Christian Kell Pavel Hok Silke Fuhrmann Ines Kropff Marie-Therese Forster Christian Senft Volker Seifert Google Scholar Christian Kell Pavel Hok Silke Fuhrmann Ines Kropff Marie-Therese Forster Christian Senft Volker Seifert PubMed Christian Kell Pavel Hok Silke Fuhrmann Ines Kropff Marie-Therese Forster Christian Senft Volker Seifert Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.